Anharmonicity, mode-coupling and entropy in a fluctuating native protein

A. Kabakçıoğlu, D. Yuret, M. Gür, B. Erman. 2010 Phys. Biol. 7 046005 doi: 10.1088/1478-3975/7/4/046005 (PDF, PDF, HTML, Online, Hermite code)

Abstract: We develop a general framework for the analysis of residue fluctuations that simultaneously incorporates anharmonicity and mode-coupling in a unified formalism. We show that both deviations from the Gaussian model are important for modeling the multidimensional energy landscape of the protein Crambin (1EJG) in the vicinity of its native state. The effect of anharmonicity and mode-coupling on the fluctuational entropy is in the order of a few percent.

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Istanbul Marathon 2010

Some pictures from the Istanbul Marathon...

Here is our route from runkeeper.com:



Some useful links:
evolutionrunning.com: How to run without injury.
Galloway's Marathon book: Everybody can do it!
Born to run: To get inspired.

And some pictures:

























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