September 30, 2014

Mode coupling points to functionally important residues in myosin II.

Onur Varol, Deniz Yuret, Burak Erman and Alkan Kabakçıoğlu. 2014. Proteins: Structure, Function, and Bioinformatics, vol 82, no 9, pp 1777--1786, September. (PDF)

Abstract: Relevance of mode coupling to energy/information transfer during protein function, particularly in the context of allosteric interactions is widely accepted. However, existing evidence in favor of this hypothesis comes essentially from model systems. We here report a novel formal analysis of the near-native dynamics of myosin II, which allows us to explore the impact of the interaction between possibly non-Gaussian vibrational modes on fluctuational dynamics. We show that an information-theoretic measure based on mode coupling alone yields a ranking of residues with a statistically significant bias favoring the functionally critical locations identified by experiments on myosin II.

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